KLAMATH RW MAX 60CPS

Klamath RW max

algali, AFA-fitocromo – che rendono la PEA attiva ed efficace. Le MAO-B sono gli enzimi che scompongono le monoamine, come la PEA e la dopamina, limitandone l’effetto. Inoltre a partire dai 40 anni l’azione delle MAO-B aumenta mentre la disponibilità di alcune monoamine, come la dopamina, diminuisce. In questo contesto la supplementazione con Klamath RW max può essere utile.
Acidi fenolici
Come l’acido caffeico, dotati anch’essi di elevate proprietà antiossidanti e antinfiammatorie. I polifenoli sono infatti noti per la loro attività di “scavenger”, distinti in gruppi differenti per la loro struttura molecolare.
Disponibile in 2 versioni capsule e in gocce.

Ingredienti
Nelle capsule:
microalghe klamath RW max (Aphanizomenon Flos Aquae); creamy (patata polvere.
Nelle gocce:
mela succo concentrato; glicerina vegetale; acqua purificata; miele d'Acacia; microalghe klamath RW max (Aphanizomenon Flos Aquae); aroma naturale fragola; pompelmo (Citrus grandis L. - Osbeck e/o Citrus x paradisi MacFayden) semi e/o frutto estratto secco, conservante: potassio sorbato; acidificante: acido citrico.

Modalità d'uso
Capsule: assumere 2 - 3 capsule, due volte al giorno.
Gocce: assumere 20 gocce (1 ml) disciolte in poca acqua o direttamente sotto la lingua, 2 - 3 volte al giorno.

Avvertenze
Non superare la dose giornaliera raccomandata.
Tenere fuori dalla portata dei bambini al di sotto dei tre anni di età.
Gli integratori non vanno intesi come sostituti di una dieta variata.
Per donne in gravidanza o in allattamento e bambini si raccomanda di sentire il parere del medico.

Conservazione
Conservare in luogo fresco e asciutto.

Caratteristiche nutrizionali

Vitamine per 3 g di Klamat RW max
	quantità	LARN/*RDA
Vitamina A( da caroteni)	0,9 mg	100 %*
Vitamina B1	750 µg	50 %*
Riboflavina (B2)	115 µg	7 %*
Niacina (B3)	12 mg	66 %*
Acido Pantotenico (B5)	4,65 mg	75 %*
Piridossina (B6)	85 µg	4,5 %*
Acido Folico (B9)	120 µg	60 %*
Cobalamina (B12)	3 - 4 µg	100 %*
Vitamina C	6 mg	10 %
Vitamina E	840 µg	8,4 %
Vitamina K	100 µg	oltre 100 %*

Minerali	contenuto per 3 g RW max	% LARN*
Calcio	30 - 45 mg	3 - 5 %
Fosforo	48 mg	6 %
Ferro	5 - 12 mg	35 - 85 %
Magnesio	9 mg	3 %
Zinco	120 µg	0,8 %
Iodio	54 µg	36 %
Fluoro	24 µg	2 %
Selenio	2, 5 mg	100 %
Manganese	3 µg	5 %
Cromo	90 µg	9 %
Molibdeno	14 µg	30 %
Vanadio	9 µg	90 %
Boro	33 µg	3,3 %

Formato
Confezione da 60 capsule.
Flacone da 50 ml.

Cod. NNK6/ NKL.

Bibliografia
- Baroni, L., et al., Effect of a Klamath algae product (“AFA-B12”) on blood levels of vitamin B12 and homocysteine in vegan subjects: a pilot study. Int J Vitam Nutr Res, 2009. 79(2): p. 117- 23.
- Kushak R. I., D.C., Winter H. S., The Effect of Blue-Green Algae Aphanizomenon Flos Aquae on Nutrient Assimilation in Rats. The Journal of the American Nutraceutical Association, 2001. 3(4): p. 34.
- Kushak R., V.E., Drapeau C., Winter H., Effect of algae Aphanizomenon flos-aquae on digestive enzyme activity and polyunsaturated fatty acids level in blood plasma. Gastroenterology, 1999. 116:A559.
- Benedetti, S.S.S., Stato antiossidante e perossidazione lipidica in risposta alla supplementazione con alga Klamath. Medicina Naturale, 2003. 6: p. pp. 67-71.
- Mayne, S.T., Beta-carotene, carotenoids, and disease prevention in humans. FASEB J, 1996. 10(7): p. 690-701.
- Pryor, W.A., W. Stahl, and C.L. Rock, Beta carotene: from biochemistry to clinical trials. Nutr Rev, 2000. 58(2 Pt 1): p. 39-53.
- Kamat JP, B.K., Devasagayam TP., Chlorophyllin as an effective antioxidant against membrane damage in vitro and ex vivo. Biochim Biophys Acta. 2000 Sep 27;1487(2-3):113-27., 2000. Sep 27;1487(2-3):113-27.
- Boloor KK, K.J., Devasagayam TP., Chlorophyllin as a protector of mitochondrial membranes against gamma-radiation and photosensitization. Toxicology, 2000. Nov 30;155(1-3):63-71.
- Bhat, V.B. and K.M. Madyastha, C-phycocyanin: a potent peroxyl radical scavenger in vivo and in vitro. Biochem Biophys Res Commun, 2000. 275(1): p. 20-5.
- Vadiraja, B.B., N.W. Gaikwad, and K.M. Madyastha, Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicity in rats. Biochem Biophys Res Commun, 1998. 249(2): p. 428-31.
- Romay, C., N. Ledon, and R. Gonzalez, Phycocyanin extract reduces leukotriene B4 levels in arachidonic acid-induced mouse-ear inflammation test. J Pharm Pharmacol, 1999. 51(5): p. 641-2.
- Gonzalez, R., et al., Anti-Inflammatory Activity of Phycocyanin Extract in Acetic Acid-Induced Colitis in Rats. Pharmacol Res, 1999. 39(1): p. 1055-1059.
- Benedetti, S., et al., Oxygen radical absorbance capacity of phycocyanin and phycocyanobilin from the food supplement Aphanizomenon flos-aquae. J Med Food, 2010. 13(1): p. 223-7.
- Rimbau, V., et al., Protective effects of C-phycocyanin against kainic acid-induced neuronal damage in rat hippocampus. Neurosci Lett, 1999. 276(2): p. 75-8.
- Sun, Y., et al., The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats. Environ Toxicol Pharmacol, 2011. 32(2): p. 168-74.
- Federici, M., et al., Trace amines depress GABA B response in dopaminergic neurons by inhibiting G-betagamma-gated inwardly rectifying potassium channels. Mol Pharmacol, 2005. 67(4): p. 1283-90.
- Xie, Z. and G.M. Miller, Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther, 2008. 325(2): p. 617-28.
- Yoneda, F., et al., Structure-activity studies leading to (-)1-(benzofuran-2-yl)-2-propylaminopentane, ((-)BPAP), a highly potent, selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain. Bioorg Med Chem, 2001. 9(5): p. 1197-212.
- Kosa, E., et al., Effects of beta-phenylethylamine on the hypothalamo-pituitary-adrenal axis in the male rat. Pharmacol Biochem Behav, 2000. 67(3): p. 527-35.
- Kushak R, D.C., Van Cott E, Winter H, Blue-green alga Aphanizomenon flos-aquae as a source of dietary polyunsaturated fatty acids and a hypocholesterolemic agent. American Chemical Society, Chemistry and nutrition, National Meeting. Anaheim, CA, 1999. A045(Jana Vol. 3, No. 4).
- Rafail, I.K., Favorable Effects of Blue Green Algae Aphanizomenon Flos Aquae on Rat Plasma Lipid. Journal of the American Nutraceutical Association, 2000. 2(3): p. pp.59-65.
- Kushak R., D.C., Winter H.S., The Effect of Blue-Green Algae Aphanizomenon Flos-Aquae on Nutrient Assimilation in Rats. Journal of American Nutraceutical Association, 2001. 3(4): p. 35-39.
- Long, J., et al., Neuronal mitochondrial toxicity of malondialdehyde: inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria. Neurochem Res, 2009. 34(4): p. 786-94.
- Reddy, C.M., et al., Selective inhibition of cyclooxygenase-2 by C-phycocyanin, a biliprotein from Spirulina platensis. Biochem Biophys Res Commun, 2000. 277(3): p. 599-603.
- Romay, C., N. Ledon, and R. Gonzalez, Further studies on antiinflammatory activity of phycocyanin in some animal models of inflammation. Inflamm Res, 1998. 47(8): p. 334-8.
- Jensen G.S. et al., Consumption of Aphanizomenon flos aquae has rapid effects on the circulation and function of immune cells in humans., in Journal of the American Nutraceutical Association, 2000 (2): 50–58.
- Pough N. et al., Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, Aphanizomenon flos-aquae and Chlorella pyrenoidosa, in Planta Medica, 2001 (67): 737– 742.
- Hart A.N. et al., Natural killer cell activation and modulation of chemokine receptor profile in vitro by an extract from the cyanophyta Aphanizomenon flos-aquae, in Journal of Med Food, 2007 Sep;10(3):435-41.
- Benedetti, Y., Neuromodulatory and neuroprotective activity of the micro-algae Aphanizomenon Flos Aquae. University of Urbino, Faculty of Science, Thesis for Doctorate in Biochemical and Pharmacological Methodologies, 2007.
- Yang, J.Q., et al., Protection of mouse brain from aluminuminduced damage by caffeic acid. CNS Neurosci Ther, 2008. 14(1): p. 10-6.
- Scoglio, S., et al., Effect of a 2-month treatment with Klamin, a Klamath algae extract, on the general well-being, antioxidant profile and oxidative status of postmenopausal women. Gynecol Endocrinol, 2009. 25(4): p. 235-40.
- Khan, M., et al., C-phycocyanin protects against ischemiareperfusion injury of heart through involvement of p38 MAPK and ERK signaling. Am J Physiol Heart Circ Physiol, 2006. 290(5): p. H2136-45.
- Riss, J., et al., Phycobiliprotein C-phycocyanin from Spirulina platensis is powerfully responsible for reducing oxidative stress and NADPH oxidase expression induced by an atherogenic diet in hamsters. J Agric Food Chem, 2007. 55(19): p. 7962-7.
- Nagaoka, S., et al., A novel protein C-phycocyanin plays a crucial role in the hypocholesterolemic action of Spirulina platensis concentrate in rats. J Nutr, 2005. 135(10): p. 2425- 30.
- Madhyastha, H.K., et al., uPA dependent and independent mechanisms of wound healing by C-phycocyanin. J Cell Mol Med, 2008. 12(6B): p. 2691-703.